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8-Bromo-cGMP sodium

Name: 8-Bromo-cGMP sodium
Brand: TargetMol
SKU: T14064
Price: 162 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14064Cas No. 51116-01-9

8-Bromo-cGMP sodium is a PKG activator, a membrane-permeable analog of cGMP. 8-Bromo-cGMP sodium has pain-relieving and vasodilatory effects, significantly inhibits Ca2+ macroscopic currents, and inhibits high K+-stimulated insulin release.

8-Bromo-cGMP sodium

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Purity: 99.45%

Catalog No. T14064Cas No. 51116-01-9

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$55	In Stock	In Stock
10 mg	$89	In Stock	In Stock
25 mg	$162	In Stock	In Stock
50 mg	Preferential	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.45%

Appearance:Solid

Color:Yellow

Resource Download

COA HPLC HNMR PNMR

Product Introduction

Bioactivity

Description	8-Bromo-cGMP sodium is a PKG activator, a membrane-permeable analog of cGMP. 8-Bromo-cGMP sodium has pain-relieving and vasodilatory effects, significantly inhibits Ca2+ macroscopic currents, and inhibits high K+-stimulated insulin release.
In vitro	8-Bromo-cGMP sodium (1 µM-0.1 mM) can inhibit acetylcholine-induced increases in intracellular calcium concentrations.[1] 8-Bromo-cGMP sodium (1-100 μM; 16 h) induces the synthesis of HO-1 protein in a concentration-dependent fashion.[2] 8-Bromo-cGMP sodium (1-100 μM; 8 h) increases the resistance of LLC-PK1 cells to CsA toxicity in concentration-dependently.[2]
In vivo	8-Bromo-cGMP sodium (0.3, 1, 3 nM; intrathecal administration; 10 min before the test; male ICR mice) significantly increases tail-flick latency in Vincristine-treated mice to the levels observed in vehicle-treated naive mice in a dose-dependent manner.[3] Additionally, 8-Bromo-cGMP sodium (10 mg/kg; iv; single dose) induces vasodilator responses in WT littermates and eNOS-Tg mice in the C57BL/6 background (19-35 g).[4]

Chemical Properties

Molecular Weight	446.09
Formula	C₁₀H₁₀BrN₅NaO₇P
Cas No.	51116-01-9
Smiles	BrC1=NC(C(N=C(N2)N)=O)=C2N1[C@H]3[C@@H]([C@@]4([H])[C@](COP([O-])(O4)=O)([H])O3)O.[Na+]
Relative Density.	2.96 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 101 mg/mL (226.41 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.2417 mL	11.2085 mL	22.4170 mL	112.0850 mL
5 mM	0.4483 mL	2.2417 mL	4.4834 mL	22.4170 mL
10 mM	0.2242 mL	1.1209 mL	2.2417 mL	11.2085 mL
20 mM	0.1121 mL	0.5604 mL	1.1209 mL	5.6043 mL
50 mM	0.0448 mL	0.2242 mL	0.4483 mL	2.2417 mL
100 mM	0.0224 mL	0.1121 mL	0.2242 mL	1.1209 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc